Artistic image of telomeresAME Laboratory: Aging, Metabolism and Emotion

Navigation bar with links to pages



Official CRONA logo

Caloric Restriction with Optimal Nutrition & Aging Study

In non-human species like rats, yeast, mice, flies, worms, fish, and even rhesus monkeys, caloric restriction causes lifespan to increase, sometimes by ten-fold. The Caloric Restriction with Optimal Nutrition & Aging (CRONA) study tests whether long-term human calorie restrictors might also have signs of slowed aging. This project is in collaboration with former postdoctoral fellow Dr. A. Janet Tomiyama, now at the Departments of Psychology and Nutritional Sciences at Rutgers University.

P.I.: Janet Tomiyama
Co-P.I.s: Elissa Epel and Elizabeth Blackburn

Learn more about it from Dr. Janet Tomiyama in this video.

Exercise and Cell Aging

Exercise and Cell Aging Study

The Exercise and Cell Aging study is the first human randomized clinical trial that tests whether an aerobic exercise intervention can boost telomerase levels in sedentary and unfit young to mid-life adults. Exercise is well known to benefit individuals biologically, but to date, only cross-sectional work highlights the associations between a healthy physical activity regimen and telomere biology in humans. This study is underway at Columbia University in collaboration with Dr.'s Richard Sloan and Daichi Shimbo, in the Division of Behavioral Medicine in the Psychiatry Department.

P.I.: Elissa Epel
Co-P.I.s: Eli Puterman & Richard Sloan


HEART: Health Enhancement Resilience Training, a mobile health intervention

Drawing from principles of evidence-based mindfulness stress-reduction, we are developing and testing a smart phone application that aims to reduce stress, increase emotional resilience, and slow the effects of stress related cellular aging. The app will include very brief "in the moment" exercises, social interaction and bio-sensor monitoring (breath-rate and heart rate variability), as well as tracking and feedback. This project includes two main phases, (I) an iterative design approach with rapid prototyping and user feedback to determine effective messaging and feature design and (II) a pilot test of the feasibility, efficacy and effectiveness of the smart phone intervention by assessing app use and engagement, telomere length and other biomarkers of stress and cellular aging, and stress related behaviors.

P.I.: Elissa Epel
Co-P.I.: Eve Kupferman

Know Your Telomeres

The Know Your Telomeres Study examined change in telomere length as a function of health behaviors and stress levels over the course of one year in 250, 50 to 65 year old healthy and community-dwelling women. In the study, half the women were told their telomere length at the start of the study, and all women were followed for one year to examine the effects of information about one's own personal telomere length on behaviors, and the possible resulting changes in telomere length at followup.

Co-PIs: Eli Puterman, Elissa Epel
Co-Investigators: Elizabeth Blackburn, Jue Lin,
Study Coordinator: Samantha Schilf

MAMAS Study Logo

Maternal Adiposity, Metabolism, and Stress Study

Carrying excess weight can increase the risk of health problems during pregnancy, and predicts excess gain during the short period of gestation. The MAMAS study is built on the premise that simple recommendations for diet and exercise may not be enough to help women maintain a healthy weight during pregnancy. The goal of the study is to learn if providing stress reduction skills and mindful eating training, in addition to encouraging good nutrition and physical activity, will help low- to middle-income overweight women achieve healthy weight gain during pregnancy and reduce stress. The study will also follow the health and temperament of the babies (led by Nicki Bush, Ph.D.)

Multiple P.I.s: Elissa Epel, Barbara Laraia, & Nancy Adler
Project Director: Kimberly Coleman-Phox

Stress, AGing, and Emotions Study in Men (Mr. SAGE)

This study examines bidirectional effects between daily psychological processes, stress arousal, and nightly sleep, among of fathers of children with autism spectrum disorder. A complementary study to SAGE (see below), it also examines daily dyadic interactions within couples coping with the stress of parenting and how these dynamics affect nightly sleep. Lastly, it examines how these relationships might change after a mindfulness based parenting stress intervention.

P.I.s: Aric Prather & Elissa Epel
Study Coordinator: Amanda Gilbert


Regular Exercise and Caregiver Health (REACH) Study

The goal of this study will be to examine whether an aerobic activity training intervention will increase cellular health, improve exercise capacity and blood pressure, and decrease psychological distress over three months in 40 caregivers compared to 40 age-matched wait list control caregivers of family members who have been diagnosed with Alzheimer's Disease or dementia. We are hoping to examine how the stress-disease link can be broken when regular physical activity regimens are implemented.

P.I.: Eli Puterman, PhD
Co-Investigators: Elissa Epel, PhD, Richard Sloan, PhD, Kirsten Johansen, MD, Aric Prather, PhD, Martin Picard, PhD, Elizabeth Blackburn, PhD, and Jue Lin, PhD
Study Coordinator: Samantha Schilf

Woman meditating.

The Relaxation and Retreat Study

Does going to a resort for a week have the same effects as being in a meditation retreat, at the same resort? With a collaborative group of researchers, we examined the psychological stress processes, self-identity, and aging biology of healthy women randomized into a resort or meditation retreat group. The retreat group was taught body and mind awareness, mantra meditation, and self-reflection. We are examing the short term changes in cell function and well-being (over days) and a month later.

P.I.s: Elissa Epel and Eli Puterman
Co-Investigators: Elizabeth Blackburn, Jue Lin, Cassandra Vieten, Rudi Tanzi, Eric Schadt, Robert Rissman, Steve Wagner, Mike Raffi
Study Coordinators: Samantha Schilf and Amanda Gilbert

Social Status, Cellular Aging, and Mortality

Social Status, Cellular Aging, and Mortality

Using data from a national health survey, this study will be the first to examine telomere length in a nationally representative sample, expanding on past findings linking socioeconomic status (SES) to shorter telomere length, and telomere length to mortality. The study examines these relationships in a racially and ethnically diverse sample, and moderating effects of genetic vulnerabilities, as well as mediating effects of health behaviors.

P.I.: Elissa Epel
Co-P.I.: Belinda Needham


Stress, AGing, and Emotions Study (SAGE)

SAGE, the Stress Aging and Emotions study for parents, is the third in a series of examinations of how the chronic stress of being a family caregiver affects cellular aging. Drawing on a sample of mothers of children on the autism spectrum, the study seeks to understand how psychological stress affects the body and mind. We aim to identify patterns of vulnerability and resilience to stress, to help with development of a hardiness intervention. We measure biological aging primarily by looking at immune cell telomeres, which form the protective caps on the ends of chromosomes, as well as telomerase, the reparative enzyme that keeps telomeres in good working order. Telomeres appear to act as a cellular clock that runs faster under physiological and psychological stress. The intensive study of resilient coping will help shape interventions.

P.I.: Elissa Epel
Co-P.I.: Elizabeth Blackburn
Project Director: Justine Arenander

SEED Study Logo

SEED (Stress, Eating, and Early Development)

Environmental influences during the first years of life, beginning in the womb, are strong determinants for later life health.

Accumulating evidence from prenatal programming and developmental research shows how early life stress and poor nutrition can affect health across the life course.

Can better nutrition and lower stress during pregnancy improve a baby's nervous system development and metabolism?

In this study, we follow the offspring born to women in the MAMA's prenatal intervention study. We examine how offspring body composition, temperament, emotion regulation, and executive function develop over the first four years of life, and whether those babies born to women in the intervention group develop more optimally than those born to women from a "treatment as usual group."

P.I.: Nicki Bush
Co-P.I.s: Elissa Epel, Barbara Laraia, Nancy Adler

SHE Study Logo

Stress, Hormones, and Eating Study

The SHE study seeks to better understand facets of Food Addiction. It examines how women's levels of stress and natural opioids in the brain are related to weight and cravings for certain comfort foods. Our ultimate goal is to develop a biological test that will help people know how opioid dependent they are, and what type of eating/weight interventions might help them the most.

P.I.s: Elissa Epel, Barbara Laraia, & Nancy Adler

SHINE Study Logo

The SHINE Study: Supporting Health by Integrating Nutrition and Exercise

SHINE is a clinical trial that examines the effects of two different 6-month weight loss programs for obese, non-diabetic adults on weight, body fat, and psychological well-being. The two programs both include nutrition and exercise components, as well as stress management techniques aimed at long-term weight loss. The key outcomes include weight loss and maintenance, body fat distribution, insulin sensitivity, psychological well-being, stress hormones, immune function, and cell aging.

P.I.: Rick Hecht
Co-P.I.: Elissa Epel
Project Director: Patty Moran


UCSF home page UCSF home page About UCSF Search UCSF UCSF Medical Center Link to the AME Home Page Link to the AME News Page Link to the AME People Page Link to a page with Elissa Epel's publications Link to the AME Research Page Link to the AME Media and Resources Page Link to the AME Contact Page Link to the AME Opportunities Page